Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 16/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21119517 | 0.85 | HSD17B10 (0.54) | GPBAR1PTGS1PTGS2HSD17B10CYP3A4 | |
| SCHEMBL3724318 | 0.77 | PTGS1 (0.57) | GPBAR1PTGS1PTGS2HSD17B10CYP3A4 | |
| SCHEMBL10394013 | 0.74 | PTGS1 (0.66) | GPBAR1PTGS1PTGS2HSD17B10CYP3A4 | |
| SCHEMBL10083918 | 0.74 | PTGS1 (0.66) | GPBAR1PTGS1PTGS2HSD17B10CYP3A4 | |
| SCHEMBL27311110 | 0.73 | PTGS1 (0.54) | GPBAR1PTGS1PTGS2HSD17B10CYP2C19 | |
| SCHEMBL6254381 | 0.73 | PTGS1 (0.47) | GPBAR1PTGS1PTGS2HSD17B10CYP2C19 | |
| SCHEMBL21120027 | 0.73 | HSD17B10 (0.56) | GPBAR1PTGS1PTGS2HSD17B10CYP3A4 | |
| SCHEMBL10520547 | 0.72 | HSD17B10 (0.76) | GPBAR1HSD17B10CYP3A4CYP2C19KMT2A | |
| SCHEMBL3545014 | 0.72 | GPBAR1 (0.79) | GPBAR1HSD17B10CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL14258658 | 0.71 | PTGS1 (0.62) | GPBAR1PTGS1PTGS2HSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378428-B2 | Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-05-27 | — | — | US | disclosed |