Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3202497 | 0.88 | PDE4B (0.56) | PDE4BPDE4APDE4D | |
| SCHEMBL3202486 | 0.88 | PDE4B (0.56) | PDE4BPDE4APDE4D | |
| SCHEMBL3216966 | 0.82 | PDE4B (0.55) | PDE4BPDE4APDE4D | |
| SCHEMBL3216960 | 0.82 | PDE4B (0.55) | PDE4BPDE4APDE4D | |
| SCHEMBL3202025 | 0.81 | PDE4B (0.73) | PDE4BPDE4APDE4D | |
| SCHEMBL3202020 | 0.81 | PDE4B (0.73) | PDE4BPDE4APDE4D | |
| SCHEMBL3202928 | 0.81 | PDE4B (0.71) | PDE4BPDE4APDE4DCYP3A4 | |
| SCHEMBL3202935 | 0.81 | PDE4B (0.71) | PDE4BPDE4APDE4DCYP3A4 | |
| SCHEMBL3206993 | 0.78 | PDE4B (0.59) | PDE4BPDE4APDE4DCYP3A4 | |
| SCHEMBL3206987 | 0.78 | PDE4B (0.59) | PDE4BPDE4APDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297106-A1 | PHENOXYPYRIDINYLAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PDE4 MEDIATED DISEASE STATES | AstraZeneca AB (SE) | 2011-03-23 | — | — | EP | disclosed |