Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.81 |
| ▸ | TNK2 | Q07912 | 15/20 | 0.69 |
| ▸ | MAP4K2 | Q12851 | 15/20 | 0.69 |
| ▸ | BMX | P51813 | 6/20 | 0.54 |
| ▸ | BCR | P11274 | 1/20 | 0.54 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.54 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FES | P07332 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.52 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14213969 | 0.92 | ABL1 (0.69) | ABL1TNK2MAP4K2BMXBCR | |
| SCHEMBL13523233 | 0.92 | ABL1 (0.68) | ABL1TNK2MAP4K2BMXBCR | |
| SCHEMBL3135794 | 0.89 | ABL1 (1.00) | ABL1TNK2MAP4K2BMXBCR | |
| SCHEMBL14213879 | 0.89 | ABL1 (0.64) | ABL1TNK2MAP4K2BMXBCR | |
| SCHEMBL14213432 | 0.87 | TNK2 (0.69) | ABL1TNK2MAP4K2BMXBCR | |
| SCHEMBL13523238 | 0.86 | TNK2 (0.67) | ABL1TNK2MAP4K2BMXBCR | |
| SCHEMBL13523328 | 0.84 | TNK2 (0.63) | ABL1TNK2MAP4K2BMXBCR | |
| SCHEMBL3129856 | 0.81 | ABL1 (0.86) | ABL1TNK2MAP4K2BMXBCR | |
| SCHEMBL14213497 | 0.81 | TNK2 (0.63) | ABL1TNK2MAP4K2BMXBCR | |
| SCHEMBL3140798 | 0.81 | ABL1 (0.85) | ABL1TNK2MAP4K2BMXBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371750-B2 | Diseases with abnormal activation of the Abl, BCR-Abl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, alpha and beta SAPK2 kinases; antiproliferative; pyrrolo[2,3-d]pyrimidine-7-carboxylic acid [3-phenylcarbamoyl-phenyl]-amides and pyrrolo[3,2-c]pyridine analogs | IRM LLC (BM) | 2008-05-13 | — | — | US | disclosed |