Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMX | P51813 | 16/20 | 0.60 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.55 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.52 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13521817 | 0.82 | BMX (0.65) | BMXTNK2MAP4K2ABL1BCR | |
| SCHEMBL3135665 | 0.80 | TNK2 (0.84) | BMXTNK2MAP4K2ABL1BCR | |
| SCHEMBL13521818 | 0.79 | TNK2 (0.77) | BMXTNK2MAP4K2ABL1BCR | |
| SCHEMBL3827669 | 0.78 | TNK2 (0.66) | BMXTNK2MAP4K2ABL1BCR | |
| SCHEMBL3136039 | 0.78 | BMX (0.57) | BMXTNK2MAP4K2ABL1BCR | |
| SCHEMBL3139709 | 0.78 | TNK2 (0.73) | BMXTNK2MAP4K2ABL1BCR | |
| SCHEMBL3139610 | 0.77 | TNK2 (0.72) | BMXTNK2MAP4K2ABL1BCR | |
| SCHEMBL3139703 | 0.77 | BMX (0.59) | BMXTNK2MAP4K2ABL1BCR | |
| SCHEMBL13523332 | 0.76 | TNK2 (0.71) | BMXTNK2MAP4K2ABL1BCR | |
| SCHEMBL3134937 | 0.75 | TNK2 (0.69) | BMXTNK2MAP4K2ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371750-B2 | Diseases with abnormal activation of the Abl, BCR-Abl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, alpha and beta SAPK2 kinases; antiproliferative; pyrrolo[2,3-d]pyrimidine-7-carboxylic acid [3-phenylcarbamoyl-phenyl]-amides and pyrrolo[3,2-c]pyridine analogs | IRM LLC (BM) | 2008-05-13 | — | — | US | disclosed |