Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 7/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.55 |
| ▸ | CSF1R | P07333 | 5/20 | 0.49 |
| ▸ | DAPK1 | P53355 | 3/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 4/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3136129 | 0.92 | CSF1R (0.60) | FGFR4FGFR1FGFR2FGFR3CSF1R | |
| SCHEMBL14214083 | 0.88 | FGFR4 (0.44) | FGFR4FGFR1FGFR2FGFR3TNK2 | |
| SCHEMBL3139491 | 0.87 | TNK2 (0.56) | FGFR4FGFR1FGFR2FGFR3CSF1R | |
| SCHEMBL3139460 | 0.86 | CSF1R (0.61) | FGFR4FGFR1FGFR2FGFR3CSF1R | |
| SCHEMBL3126954 | 0.84 | LCK (0.50) | FGFR4FGFR1FGFR2FGFR3CSF1R | |
| SCHEMBL3126128 | 0.82 | LCK (0.51) | FGFR1FGFR3CSF1RDAPK1TNK2 | |
| SCHEMBL3140068 | 0.82 | TNK2 (0.49) | FGFR4FGFR1FGFR2FGFR3CSF1R | |
| SCHEMBL3144335 | 0.81 | TNK2 (0.57) | FGFR4FGFR1FGFR2FGFR3CSF1R | |
| SCHEMBL3134068 | 0.81 | LCK (0.48) | FGFR4FGFR1FGFR2FGFR3CSF1R | |
| SCHEMBL13523311 | 0.79 | FGFR4 (0.53) | FGFR4FGFR1FGFR2FGFR3TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371750-B2 | Diseases with abnormal activation of the Abl, BCR-Abl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, alpha and beta SAPK2 kinases; antiproliferative; pyrrolo[2,3-d]pyrimidine-7-carboxylic acid [3-phenylcarbamoyl-phenyl]-amides and pyrrolo[3,2-c]pyridine analogs | IRM LLC (BM) | 2008-05-13 | — | — | US | disclosed |