Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.54 |
| ▸ | TXK | P42681 | 1/20 | 0.47 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.47 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL373480 | 0.92 | SYK (0.64) | SYKTXKKARS1SLK | |
| SCHEMBL374054 | 0.89 | SYK (0.66) | SYKTXKKARS1SLK | |
| SCHEMBL15939061 | 0.87 | SYK (0.62) | SYKTXKKARS1SLK | |
| SCHEMBL374052 | 0.86 | SYK (0.65) | SYKTXKKARS1SLK | |
| SCHEMBL373481 | 0.79 | SYK (0.61) | SYKTXKKARS1SLK | |
| SCHEMBL374055 | 0.78 | SYK (0.58) | SYKTXKKARS1SLK | |
| SCHEMBL374139 | 0.75 | SYK (0.61) | SYKTXKKARS1SLK | |
| SCHEMBL588885 | 0.75 | SYK (0.46) | SYK | |
| SCHEMBL30480367 | 0.75 | SYK (0.46) | SYK | |
| SCHEMBL3788788 | 0.74 | SYK (0.54) | SYKTXKKARS1SLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080114024-A1 | 1,6 NAPHTHYRIDINES USEFUL AS INHIBITORS OF SYK KINASE | CYWIN CHARLES L | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114024-A1 | 1,6 NAPHTHYRIDINES USEFUL AS INHIBITORS OF SYK KINASE | SYK, IRAK1, IRAK3 | SYK 1/4885TXK 514/4885KARS1 1169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.