Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 19/20 | 0.43 |
| ▸ | CCR7 | P32248 | 3/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.41 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214579 | 0.92 | CXCR2 (0.47) | CXCR2CCR7CXCR1CX3CR1 | |
| SCHEMBL14214648 | 0.90 | CXCR2 (0.50) | CXCR2CCR7CXCR1CX3CR1 | |
| SCHEMBL14214572 | 0.88 | CXCR2 (0.43) | CXCR2CCR7CXCR1RAB9A | |
| SCHEMBL14214580 | 0.86 | CXCR2 (0.41) | CXCR2CCR7CXCR1CX3CR1RAB9A | |
| SCHEMBL14214650 | 0.85 | CXCR2 (0.51) | CXCR2CCR7CXCR1RAB9A | |
| SCHEMBL3606012 | 0.84 | CXCR2 (0.54) | CXCR2CX3CR1 | |
| SCHEMBL14214570 | 0.83 | CXCR2 (0.42) | CXCR2CCR7CXCR1CX3CR1 | |
| SCHEMBL14214649 | 0.83 | CXCR2 (0.39) | CXCR2CCR7CXCR1 | |
| SCHEMBL14214574 | 0.80 | ADORA2A (0.45) | CXCR2CCR7CXCR1RAB9A | |
| SCHEMBL14214462 | 0.78 | CXCR2 (0.47) | CXCR2CCR7CXCR1CX3CR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061740-A1 | PYRIMIDINES AND THEIR USE AS CXCR2 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2008-05-29 | — | — | WO | disclosed |