Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.84 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.84 |
| ▸ | LCK | P06239 | 3/20 | 0.84 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.84 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.84 |
| ▸ | FLT1 | P17948 | 2/20 | 0.84 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.84 |
| ▸ | AURKA | O14965 | 1/20 | 0.84 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.84 |
| ▸ | JAK2 | O60674 | 1/20 | 0.84 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.84 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.84 |
| ▸ | PAK4 | O96013 | 1/20 | 0.84 |
| ▸ | ABL1 | P00519 | 1/20 | 0.84 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.84 |
| ▸ | FYN | P06241 | 1/20 | 0.84 |
| ▸ | CSF1R | P07333 | 1/20 | 0.84 |
| ▸ | RET | P07949 | 1/20 | 0.84 |
| ▸ | MET | P08581 | 1/20 | 0.84 |
| ▸ | PIM1 | P11309 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14214547 | 0.80 | PTK2 (0.79) | KDRPTK2LCKPDGFRBTNK2 | |
| SCHEMBL5758488 | 0.76 | ALK (0.73) | KDRPTK2LCKPDGFRBTNK2 | |
| SCHEMBL5757748 | 0.74 | ALK (0.60) | KDRPTK2LCKPDGFRBTNK2 | |
| SCHEMBL6478895 | 0.73 | PDGFRB (0.57) | KDRPTK2LCKPDGFRBTNK2 | |
| SCHEMBL14214686 | 0.72 | PTK2 (0.56) | KDRPTK2LCKPDGFRBTNK2 | |
| SCHEMBL5758463 | 0.70 | KDR (0.55) | KDRPTK2LCKPDGFRBTNK2 | |
| SCHEMBL4251626 | 0.70 | ALK (0.59) | KDRPTK2LCKPDGFRBTNK2 | |
| SCHEMBL14214691 | 0.68 | KDR (0.63) | KDRPTK2LCKPDGFRBTNK2 | |
| SCHEMBL5759796 | 0.68 | ROCK1 (0.52) | KDRPTK2LCKPDGFRBTNK2 | |
| SCHEMBL4761475 | 0.68 | EGFR (0.65) | KDRPTK2LCKPDGFRBTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |