SCHEMBL14214908

SCHEMBL14214908

CC(F)CC(C)N(C(=O)C1CCC(C)CC1)c1cc(C(C)(C)C)sc1C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR1I2 O75469 2/20 0.41
CYP2E1 P05181 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12945684 0.88 NR1I2 (0.41) NR1I2CYP2E1
SCHEMBL12446675 0.87 NR1I2 (0.39) NR1I2CYP2E1
SCHEMBL173186 0.87 NR1I2 (0.42) NR1I2CYP2E1
SCHEMBL14726674 0.87 NR1I2 (0.42) NR1I2CYP2E1
SCHEMBL173173 0.86 NR1I2 (0.40) NR1I2CYP2E1
SCHEMBL10268581 0.83 CYP2E1 (0.46) NR1I2CYP2E1
SCHEMBL10268579 0.83 CYP2E1 (0.46) NR1I2CYP2E1
SCHEMBL14647722 0.81 NR1I2 (0.39) NR1I2CYP2E1
SCHEMBL12945463 0.81 NR1I2 (0.36) NR1I2CYP2E1
SCHEMBL10264929 0.80 NR1I2 (0.40) NR1I2CYP2E1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008058393-A1 THIOPHENE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS VIROCHEM PHARMA INC. (CA) 2008-05-22 WO disclosed