Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.67 |
| ▸ | ZAP70 | P43403 | 10/20 | 0.67 |
| ▸ | SRC | P12931 | 10/20 | 0.67 |
| ▸ | CDK2 | P24941 | 6/20 | 0.61 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | BCR | P11274 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.44 |
| ▸ | ABL2 | P42684 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | DDX3X | O00571 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216062 | 0.92 | SYK (0.67) | SYKZAP70SRCCDK2FLT3 | |
| SCHEMBL14216005 | 0.91 | SYK (0.69) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14215971 | 0.90 | SYK (0.67) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216229 | 0.89 | SYK (0.66) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14215970 | 0.88 | SYK (0.62) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216155 | 0.84 | SYK (0.65) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216017 | 0.82 | SYK (0.80) | SYKZAP70SRCCDK2ABL1 | |
| SCHEMBL14216160 | 0.81 | SYK (1.00) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216274 | 0.80 | SYK (0.77) | SYKZAP70SRCCDK2ABL1 | |
| SCHEMBL14216121 | 0.79 | SYK (0.76) | SYKZAP70SRCCDK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605946-B1 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |