Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.74 |
| ▸ | ZAP70 | P43403 | 12/20 | 0.74 |
| ▸ | SRC | P12931 | 10/20 | 0.63 |
| ▸ | CDK2 | P24941 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 4/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216141 | 0.90 | SYK (0.70) | SYKZAP70SRCCDK2KDM4E | |
| SCHEMBL14216139 | 0.88 | SYK (0.67) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216306 | 0.87 | SYK (0.70) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216134 | 0.87 | SYK (0.73) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216056 | 0.87 | SYK (0.66) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL15668071 | 0.86 | SYK (1.00) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL15668072 | 0.86 | SYK (1.00) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216051 | 0.85 | ZAP70 (0.67) | SYKZAP70SRCCDK2KDM4E | |
| SCHEMBL14216156 | 0.83 | SYK (0.65) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216202 | 0.83 | SYK (0.67) | SYKZAP70SRCCDK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605946-B1 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |