Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.76 |
| ▸ | ZAP70 | P43403 | 13/20 | 0.76 |
| ▸ | SRC | P12931 | 11/20 | 0.76 |
| ▸ | CDK2 | P24941 | 9/20 | 0.65 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 4/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CDK7 | P50613 | 2/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216043 | 0.88 | SYK (0.83) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216034 | 0.88 | SYK (0.76) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216052 | 0.87 | SYK (0.77) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216038 | 0.87 | SYK (0.67) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL5036950 | 0.86 | SYK (1.00) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216026 | 0.86 | SYK (0.72) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216055 | 0.86 | SYK (0.72) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216036 | 0.84 | SYK (0.70) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216033 | 0.84 | SYK (0.70) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216133 | 0.84 | SYK (0.77) | SYKZAP70SRCCDK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605946-B1 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |