Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 14/20 | 1.00 |
| ▸ | SYK | P43405 | 14/20 | 1.00 |
| ▸ | SRC | P12931 | 12/20 | 1.00 |
| ▸ | CDK2 | P24941 | 7/20 | 1.00 |
| ▸ | CDK4 | P11802 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216081 | 0.94 | ZAP70 (0.88) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14216222 | 0.88 | CDK2 (0.79) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14216168 | 0.87 | SYK (0.77) | ZAP70SYKSRCCDK2ABL1 | |
| SCHEMBL14378969 | 0.87 | SYK (0.77) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14216198 | 0.87 | ZAP70 (0.77) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14216203 | 0.87 | SYK (0.77) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14216024 | 0.87 | ZAP70 (0.77) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14216063 | 0.87 | SRC (0.77) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14378961 | 0.85 | CDK2 (0.74) | ZAP70SYKSRCCDK2CDK4 | |
| SCHEMBL14216006 | 0.85 | SYK (0.74) | ZAP70SYKSRCCDK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605946-B1 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |