Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.77 |
| ▸ | ZAP70 | P43403 | 14/20 | 0.77 |
| ▸ | SRC | P12931 | 14/20 | 0.77 |
| ▸ | CDK2 | P24941 | 9/20 | 0.77 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216119 | 0.85 | SYK (0.77) | SYKZAP70SRCCDK2KDR | |
| SCHEMBL14216022 | 0.84 | SYK (0.79) | SYKZAP70SRCCDK2KDR | |
| SCHEMBL144714 | 0.82 | SYK (0.64) | SYKZAP70SRCCDK2KDR | |
| SCHEMBL5038586 | 0.81 | SYK (1.00) | SYKZAP70SRCCDK2CDK4 | |
| SCHEMBL5034160 | 0.81 | SYK (0.72) | SYKZAP70SRCCDK2KDR | |
| SCHEMBL5034149 | 0.81 | SYK (0.72) | SYKZAP70SRCCDK2KDR | |
| SCHEMBL5037349 | 0.81 | SYK (0.79) | SYKZAP70SRCCDK2CDK4 | |
| SCHEMBL13924509 | 0.80 | SYK (1.00) | SYKZAP70SRCCDK2 | |
| SCHEMBL5036868 | 0.80 | SYK (0.76) | SYKZAP70SRCCDK2CDK4 | |
| SCHEMBL14216163 | 0.80 | SYK (0.76) | SYKZAP70SRCCDK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605946-B1 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |