Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437996 | 0.94 | MAPT (0.53) | MAPTHTTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL14216592 | 0.89 | MAPT (0.50) | MAPTHTTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL9425659 | 0.87 | MAPT (0.67) | MAPTHTTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL1710516 | 0.86 | MAPT (0.65) | MAPTHTTALDH1A1SMN1; SMN2MAPK1 | |
| Pivalate SCHEMBL27791210 | 0.84 | MAPT (0.45) | MAPTHTTALDH1A1SMN1; SMN2MAPK1 | |
| Tert-Butyl Formate SCHEMBL27770095 | 0.82 | MAPT (0.43) | MAPTHTTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL3055471 | 0.80 | MAPT (0.60) | MAPTHTTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL28822159 | 0.79 | TSHR (0.48) | MAPTHTTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL10514216 | 0.78 | MAPT (0.44) | MAPTHTTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL15771279 | 0.77 | CYP3A4 (0.52) | MAPTHTTALDH1A1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054749-A1 | 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-05-08 | — | — | WO | disclosed |