Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | MPO | P05164 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | BLM | P54132 | 1/20 | 0.74 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.74 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | HTR1D | P28221 | 1/20 | 0.59 |
| ▸ | HTR1B | P28222 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
| ▸ | HTR1E | P28566 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13323168 | 0.87 | KDM4E (0.72) | KDM4EMAPTMEN1LMNAMPO | |
| SCHEMBL13906881 | 0.87 | KDM4E (0.72) | KDM4EMAPTMEN1LMNAMPO | |
| SCHEMBL22622531 | 0.87 | KDM4E (0.72) | KDM4EMAPTMEN1LMNAMPO | |
| SCHEMBL31000526 | 0.86 | KDM4E (0.74) | KDM4EMAPTMEN1LMNAMPO | |
| SCHEMBL20390111 | 0.86 | KDM4E (0.70) | KDM4EMAPTMEN1LMNAMPO | |
| SCHEMBL12835419 | 0.86 | KDM4E (0.70) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL23141133 | 0.85 | KMT2A (1.00) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL475350 | 0.85 | KMT2A (1.00) | KDM4EMAPTMEN1LMNAMPO | |
| SCHEMBL2726806 | 0.85 | KDM4E (0.78) | KDM4EMAPTMEN1LMNAMPO | |
| Tryptophan SCHEMBL4732053 | 0.85 | KMT2A (1.00) | KDM4EMAPTMEN1LMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169247-B2 | Tetrahydro-beta-carboline derivatives, synthesis and use thereof | SOUTHERN RESEARCH INSTITUTE (US) | 2015-10-27 | — | — | US | disclosed |
| US-20120309781-A1 | TETRAHYDRO-beta-CARBOLINE DERIVATIVES, SYNTHESIS AND USE THEREOF | SOUTHERN RESEARCH INSTITUTE (US) | 2012-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309781-A1 | TETRAHYDRO-beta-CARBOLINE DERIVATIVES, SYNTHESIS AND USE THEREOF | PDE5A, PDE3A, PDE3B | KDM4E 839/4885MAPT 2876/4885MEN1 623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.