Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.71 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.67 |
| ▸ | EGFR | P00533 | 5/20 | 0.59 |
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | BRAF | P15056 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 4/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | MET | P08581 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | LTK | P29376 | 1/20 | 0.56 |
| ▸ | TTK | P33981 | 1/20 | 0.56 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14217419 | 0.91 | AURKA (0.74) | AURKAAURKBEGFRKDRBRAF | |
| SCHEMBL14421416 | 0.88 | AURKA (0.75) | AURKAAURKBEGFRKDRBRAF | |
| SCHEMBL14421356 | 0.88 | AURKA (0.68) | AURKAAURKBEGFRKDRBRAF | |
| SCHEMBL14421355 | 0.86 | KDR (0.55) | AURKAEGFRKDRALDH1A1MAPT | |
| SCHEMBL14421415 | 0.85 | AURKA (0.81) | AURKAAURKBEGFRKDRBRAF | |
| SCHEMBL14216878 | 0.82 | AURKA (0.69) | AURKAAURKBEGFRKDRBRAF | |
| SCHEMBL14421417 | 0.82 | AURKA (0.75) | AURKAAURKBEGFRKDRBRAF | |
| SCHEMBL14216876 | 0.80 | AURKA (0.69) | AURKAAURKBEGFRKDRBRAF | |
| SCHEMBL5025973 | 0.80 | AURKA (0.71) | AURKAAURKBEGFRKDRBRAF | |
| SCHEMBL14216879 | 0.80 | AURKA (0.71) | AURKAAURKBEGFRKDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299381-B1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2002000649-A9 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |