Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 5/20 | 0.56 |
| ▸ | RARA | P10276 | 1/20 | 0.51 |
| ▸ | RARB | P10826 | 1/20 | 0.51 |
| ▸ | RARG | P13631 | 1/20 | 0.51 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1792656 | 0.88 | GCK (0.57) | GCKRARARARBRARGSGMS2 | |
| SCHEMBL14018651 | 0.86 | GCK (0.54) | GCKRARARARBRARGSGMS2 | |
| SCHEMBL1792248 | 0.85 | GCK (0.54) | GCKRARARARBRARGMEN1 | |
| SCHEMBL2664864 | 0.84 | GCK (0.53) | GCKRARARARBRARGSGMS2 | |
| SCHEMBL1793057 | 0.84 | GCK (0.53) | GCKRARARARBRARGSGMS2 | |
| SCHEMBL2664861 | 0.82 | GCK (0.51) | GCKRARARARBRARGSGMS2 | |
| SCHEMBL2664858 | 0.82 | GCK (0.57) | GCKRARARARBRARGSGMS2 | |
| SCHEMBL2664862 | 0.80 | GCK (0.52) | GCKRARARARBRARGSGMS2 | |
| SCHEMBL2664865 | 0.80 | GCK (0.65) | GCKRARARARBRARGMEN1 | |
| SCHEMBL2665330 | 0.79 | GCK (0.49) | GCKRARARARBRARGSGMS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1661563-B1 | Compound effecting Glucokinase | ASTRAZENECA AB (SE) | 2008-05-28 | — | — | EP | disclosed |