SCHEMBL1421759

SCHEMBL1421759

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nearest known ligand 0.44

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 0.44
DPP4 P27487 2/20 0.33
FAP Q12884 1/20 0.33
DPP8 Q6V1X1 1/20 0.33
DPP9 Q86TI2 1/20 0.33
DPP7 Q9UHL4 1/20 0.33
LAP3 P28838 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL288204 0.90 SLC7A5 (0.52) SLC7A5DPP4FAPDPP8DPP9
SCHEMBL10530419 0.90 SLC7A5 (0.52) SLC7A5DPP4FAPDPP8DPP9
SCHEMBL27932393 0.90 SLC7A5 (0.52) SLC7A5DPP4FAPDPP8DPP9
SCHEMBL3191865 0.86 SLC7A5 (0.33) SLC7A5
SCHEMBL28172100 0.86 SLC7A5 (0.44) SLC7A5DPP4FAPDPP8DPP9
SCHEMBL28065518 0.86 SLC7A5 (0.44) SLC7A5DPP4FAPDPP8DPP9
SCHEMBL17164620 0.84 SLC7A5 (0.42) SLC7A5DPP4FAPDPP8DPP9
SCHEMBL28019556 0.83 SLC7A5 (0.46) SLC7A5DPP4FAPDPP8DPP9
SCHEMBL28327922 0.83 SLC7A5 (0.35) SLC7A5DPP4DPP7
SCHEMBL10710883 0.83 SLC7A5 (0.46) SLC7A5DPP4FAPDPP8DPP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190160188-A1 Radiolabeled Alpha-Melanocyte Stimulating Hormone Hybrid Peptide for Melanoma Targeting STC UNM (US) 2019-05-30 US claimed
US-20190160188-A1 Radiolabeled Alpha-Melanocyte Stimulating Hormone Hybrid Peptide for Melanoma Targeting STC UNM (US) 2019-05-30 US disclosed
US-10238758-B2 Radiolabeled alpha-melanocyte stimulating hormone hybrid peptide for melanoma targeting STC.UNM (US) 2019-03-26 US disclosed
US-20180273626-A1 OMALIZUMAB RESISTANT IGE VARIANTS AND THEIR USE IN ANTI-IGE THERAPY THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIO UNIV (US) 2018-09-27 US disclosed
US-9901559-B2 Compositions comprising amino acids, with pro-angiogenic activity DETERMINANTS OF METABOLISM RESEARCH LABORATORY S.R.L. (IT) 2018-02-27 US disclosed
US-20170087259-A1 RADIOLABELED ALPHA-MELANOCYTE STIMULATING HORMONE HYBRID PEPTIDE FOR MELANOMA TARGETING STC UNM (US) 2017-03-30 US disclosed
US-9463255-B1 Radiolabeled alpha-melanocyte stimulating hormone hybrid peptide for melanoma targeting STC.UNM (US) 2016-10-11 US disclosed
US-20130085170-A1 COMPOSITIONS COMPRISING AMINO ACIDS, WITH PRO-ANGIOGENIC ACTIVITY PROFESSIONAL DIETETICS S.R.L. (IT) 2013-04-04 US disclosed
EP-2296642-A1 COMPOSITIONS COMPRISING AMINO ACIDS, WITH PRO-ANGIOGENIC ACTIVITY Professional Dietetics S.r.l. (IT) 2011-03-23 EP disclosed
WO-2009147637-A1 COMPOSITIONS COMPRISING AMINO ACIDS, WITH PRO-ANGIOGENIC ACTIVITY PROFESSIONAL DIETETICS S.R.L. (IT) 2009-12-10 WO disclosed
US-20040250313-A1 Insecticidal proteins and synergistic combinations thereof SYNGENTA LIMITED (GB) 2004-12-09 US disclosed
EP-1399473-A2 INSECTICIDAL PROTEINS AND SYNERGISTIC COMBINATIONS THEREOF Syngenta Limited (GB) 2004-03-24 EP disclosed
WO-2002098911-A2 INSECTICIDAL PROTEINS AND SYNERGISTIC COMBINATIONS THEREOF SYNGENTA LIMITED (GB) 2002-12-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190160188-A1 Radiolabeled Alpha-Melanocyte Stimulating Hormone Hybrid Peptide for Melanoma Targeting MC1R, MC3R, MC4R SLC7A5 416/4885DPP4 473/4885FAP 633/4885
US-20170087259-A1 RADIOLABELED ALPHA-MELANOCYTE STIMULATING HORMONE HYBRID PEPTIDE FOR MELANOMA TARGETING MC1R, MC3R, MC4R SLC7A5 416/4885DPP4 473/4885FAP 633/4885
US-10238758-B2 Radiolabeled alpha-melanocyte stimulating hormone hybrid peptide for melanoma targeting MC1R, MC3R, MC4R SLC7A5 416/4885DPP4 473/4885FAP 633/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.