Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 3/20 | 0.56 |
| ▸ | PIP4K2B | P78356 | 2/20 | 0.56 |
| ▸ | FYN | P06241 | 3/20 | 0.54 |
| ▸ | BRAF | P15056 | 7/20 | 0.53 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | STAT1 | P42224 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13273354 | 0.85 | PIP4K2A (0.54) | PIP4K2APIP4K2BFYNBRAFCYP17A1 | |
| SCHEMBL5423116 | 0.81 | PIP4K2A (0.54) | PIP4K2APIP4K2BFYNBRAFCYP17A1 | |
| SCHEMBL4189391 | 0.78 | PIP4K2A (0.62) | PIP4K2APIP4K2BFYNBRAFCYP17A1 | |
| SCHEMBL2646435 | 0.77 | CNR1 (0.63) | PIP4K2APIP4K2BFYNBRAFCYP17A1 | |
| SCHEMBL4191864 | 0.76 | BRAF (0.70) | PIP4K2APIP4K2BFYNBRAFCYP17A1 | |
| SCHEMBL11222723 | 0.76 | CNR1 (0.64) | PIP4K2APIP4K2BFYNBRAFCYP17A1 | |
| SCHEMBL871769 | 0.74 | PIP4K2A (0.49) | PIP4K2APIP4K2BFYNBRAFCYP17A1 | |
| SCHEMBL4193284 | 0.72 | BRAF (0.59) | PIP4K2APIP4K2BFYNBRAFCYP17A1 | |
| SCHEMBL4194092 | 0.72 | BRAF (0.65) | PIP4K2APIP4K2BFYNBRAF | |
| SCHEMBL4191746 | 0.72 | BRAF (0.68) | PIP4K2APIP4K2BFYNBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061236-A2 | SULFOXIMINES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2008-05-22 | — | — | WO | disclosed |