Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 14/20 | 0.69 |
| ▸ | ABL1 | P00519 | 12/20 | 0.69 |
| ▸ | BCR | P11274 | 8/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.69 |
| ▸ | EGFR | P00533 | 2/20 | 0.69 |
| ▸ | PRKCA | P17252 | 2/20 | 0.69 |
| ▸ | KIT | P10721 | 5/20 | 0.68 |
| ▸ | JAK3 | P52333 | 1/20 | 0.67 |
| ▸ | BTK | Q06187 | 1/20 | 0.67 |
| ▸ | ITK | Q08881 | 1/20 | 0.67 |
| ▸ | KDR | P35968 | 1/20 | 0.64 |
| ▸ | ABL2 | P42684 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13492330 | 0.86 | PDGFRA (0.69) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL13492307 | 0.86 | PDGFRA (0.69) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL13492337 | 0.86 | ABL1 (0.74) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL13492360 | 0.85 | ABL1 (0.75) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL4412243 | 0.85 | PDGFRA (0.67) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL13492323 | 0.84 | PDGFRA (0.76) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL13492344 | 0.84 | ABL1 (0.73) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL3967060 | 0.83 | PDGFRA (0.66) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL2004455 | 0.83 | PDGFRA (0.91) | PDGFRAABL1BCRPDGFRBEGFR | |
| SCHEMBL23246300 | 0.82 | ABL1 (0.86) | PDGFRAABL1BCRPDGFRBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008058037-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-05-15 | — | — | WO | disclosed |