Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 19/20 | 0.67 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.55 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3918732 | 0.90 | CHEK2 (0.82) | CHEK2PKN1PKN2 | |
| SCHEMBL3921862 | 0.89 | CHEK2 (0.83) | CHEK2 | |
| SCHEMBL3916628 | 0.89 | CHEK2 (0.80) | CHEK2PKN1PKN2 | |
| SCHEMBL8613521 | 0.88 | CHEK2 (0.79) | CHEK2PKN1PKN2 | |
| SCHEMBL3925881 | 0.86 | CHEK2 (0.84) | CHEK2 | |
| SCHEMBL3928946 | 0.86 | CHEK2 (0.84) | CHEK2PKN1PKN2 | |
| SCHEMBL1380709 | 0.86 | CHEK2 (0.81) | CHEK2 | |
| SCHEMBL3916431 | 0.86 | CHEK2 (0.85) | CHEK2 | |
| SCHEMBL3921847 | 0.84 | CHEK2 (0.84) | CHEK2 | |
| SCHEMBL3921747 | 0.83 | CHEK2 (0.85) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080125358-A1 | Methods for Chk2 inhibitor patient selection | UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125358-A1 | Methods for Chk2 inhibitor patient selection | CHEK2, CHEK1, TP53 | CHEK2 1/4885PKN1 646/4885PKN2 551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.