Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 16/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807133 | 0.89 | BACE1 (0.59) | BACE1PIM1PIM3CHEK1ACKR3 | |
| SCHEMBL14216463 | 0.88 | PIM1 (0.55) | BACE1PIM1PIM3CHEK1 | |
| SCHEMBL2077918 | 0.84 | CHEK1 (0.53) | BACE1PIM1PIM3CHEK1 | |
| SCHEMBL14207012 | 0.84 | CHEK1 (0.69) | BACE1CHEK1ACKR3 | |
| SCHEMBL11886316 | 0.81 | CHEK1 (0.52) | BACE1PIM1PIM3CHEK1 | |
| SCHEMBL11886337 | 0.80 | CHEK1 (0.51) | BACE1PIM1PIM3CHEK1 | |
| SCHEMBL11886317 | 0.79 | CHEK1 (0.74) | BACE1PIM1PIM3CHEK1ACKR3 | |
| SCHEMBL3955493 | 0.78 | CHEK1 (0.52) | BACE1CHEK1ACKR3 | |
| SCHEMBL11886339 | 0.78 | CHEK1 (0.51) | BACE1PIM1PIM3CHEK1 | |
| SCHEMBL12550556 | 0.78 | PIM1 (0.55) | BACE1PIM1PIM3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008054701-A1 | 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-05-08 | — | — | WO | disclosed |