Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 3/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14572362 | 0.92 | CHEK1 (0.48) | CHEK1CCNA2CDK2CCNA1BTK | |
| SCHEMBL11931635 | 0.91 | CHEK1 (0.47) | CHEK1CCNA2CDK2CCNA1BTK | |
| SCHEMBL11931636 | 0.91 | CHEK1 (0.47) | CHEK1CCNA2CDK2CCNA1BTK | |
| SCHEMBL11931633 | 0.90 | CHEK1 (0.50) | CHEK1CCNA2CDK2CCNA1BTK | |
| SCHEMBL11931637 | 0.90 | CHEK1 (0.46) | CHEK1CCNA2CDK2CCNA1BTK | |
| SCHEMBL13794761 | 0.90 | CHEK1 (0.46) | CHEK1CCNA2CDK2CCNA1BTK | |
| SCHEMBL11931577 | 0.89 | CHEK1 (0.65) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14218635 | 0.89 | CHEK1 (0.51) | CHEK1CCNA2CDK2CCNA1TRPV3 | |
| SCHEMBL11931591 | 0.85 | CHEK1 (0.46) | CHEK1CCNA2CDK2CCNA1BTK | |
| SCHEMBL11931622 | 0.85 | CHEK1 (0.46) | CHEK1CCNA2CDK2CCNA1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008045266-A2 | PYRAZOLOPYRIMIDIWES AS CYCLIN DEPENDENT KINASE INHIBITOR | SCHERING CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |