Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12141786 | 0.95 | HSD17B10 (0.79) | TSHRHSD17B10ALOX15KDM4ELMNA | |
| SCHEMBL17547266 | 0.87 | TSHR (0.72) | TSHRHSD17B10ALOX15KDM4ELMNA | |
| SCHEMBL26981196 | 0.86 | HSD17B10 (0.91) | TSHRHSD17B10ALOX15KDM4ELMNA | |
| SCHEMBL12226466 | 0.85 | HSD17B10 (0.69) | TSHRHSD17B10ALOX15KDM4ELMNA | |
| SCHEMBL4969885 | 0.85 | HSD17B10 (0.69) | TSHRHSD17B10ALOX15KDM4ELMNA | |
| SCHEMBL23507546 | 0.82 | HSD17B10 (0.77) | TSHRHSD17B10ALOX15KDM4ELMNA | |
| SCHEMBL7904692 | 0.82 | GAA (0.63) | TSHRHSD17B10ALOX15KDM4EALDH1A1 | |
| SCHEMBL30920967 | 0.82 | HSD17B10 (0.77) | TSHRHSD17B10ALOX15KDM4ELMNA | |
| SCHEMBL27976384 | 0.82 | TSHR (0.53) | TSHRHSD17B10ALOX15KDM4ELMNA | |
| SCHEMBL31717947 | 0.82 | HSD17B10 (1.00) | TSHRHSD17B10ALOX15KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378411-B2 | Substituted thienopyrimidinones as a mitotic kinesin inhibitor | MERCK & CO., INC. (US) | 2008-05-27 | — | — | US | disclosed |
| US-7262186-B2 | Substituted pyrazolo[3,4-d] pyrimidinones as a mitotic kinesin inhibitor | MERCK & CO., INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262187-B2 | Substituted oxazolo- and thizaolopyrimidinones as a mitotic kinesin inhibitor | MERCK & CO., INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7244723-B2 | Substituted furopyrimidinones as a mitotic kinesin inhibitors | MERCK & CO., INC. (US) | 2007-07-17 | — | — | US | disclosed |