Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 17/20 | 0.58 |
| ▸ | CDK2 | P24941 | 5/20 | 0.52 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14218796 | 0.92 | CHEK1 (0.58) | CHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL14218800 | 0.92 | CHEK1 (0.61) | CHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL14218794 | 0.89 | CHEK1 (0.55) | CHEK1CDK2GSK3BCCNA2CCNA1 | |
| SCHEMBL11931073 | 0.89 | CHEK1 (0.75) | CHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL14218885 | 0.85 | CHEK1 (0.65) | CHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL14218801 | 0.85 | CHEK1 (0.60) | CHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL14542940 | 0.83 | CHEK1 (0.62) | CHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL13845589 | 0.81 | CHEK1 (0.63) | CHEK1CDK2GSK3BCCNA2CCNA1 | |
| SCHEMBL14218820 | 0.81 | CHEK1 (0.57) | CHEK1CDK2CCNA2CCNA1 | |
| SCHEMBL14218818 | 0.81 | CHEK1 (0.78) | CHEK1CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008045268-A2 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2007044441-A2 | USE OF PYRAZOLO [1 , 5 -A] PYRIMIDINE DERIVATIVES FOR INHIBITING PROTEIN KINASES METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |