Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.56 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | LYN | P07948 | 2/20 | 0.51 |
| ▸ | HCK | P08631 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 8/20 | 0.50 |
| ▸ | LDLR | P01130 | 3/20 | 0.49 |
| ▸ | KIT | P10721 | 3/20 | 0.49 |
| ▸ | PCSK9 | Q8NBP7 | 3/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.49 |
| ▸ | BCR | P11274 | 5/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 5/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580903 | 0.91 | MAP4K2 (0.65) | MAP4K2EPHB2KDRLCKLYN | |
| SCHEMBL3590408 | 0.87 | BRAF (0.47) | MAP4K2KDRLCKLYNHCK | |
| SCHEMBL3582693 | 0.83 | CSF1R (0.58) | MAP4K2EPHB2KDRLCKLYN | |
| SCHEMBL3592374 | 0.83 | MAP4K2 (0.55) | MAP4K2EPHB2KDRLCKLYN | |
| SCHEMBL3594586 | 0.81 | MAP4K2 (0.49) | MAP4K2KDRLCKLYNHCK | |
| SCHEMBL3589389 | 0.80 | MAP4K2 (0.48) | MAP4K2KDRLCKLYNHCK | |
| SCHEMBL3591101 | 0.80 | BRAF (0.54) | MAP4K2HCKBRAFMAPK14DDR2 | |
| SCHEMBL3592154 | 0.80 | BRAF (0.58) | ABL1BRAF | |
| SCHEMBL3585221 | 0.80 | BRAF (0.51) | ABL1BRAF | |
| SCHEMBL3583692 | 0.80 | BRAF (0.61) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | disclosed |