SCHEMBL14218840

SCHEMBL14218840

CNc1cc(-n2nc(C)cc2Nc2cc(NC(=O)c3cc(CN4CCCCC4)cc(C(F)(F)F)c3)ccc2C)ncn1

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BRAF P15056 19/20 0.50
CSF1R P07333 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3586278 0.99 CSF1R (0.51) BRAFCSF1R
SCHEMBL3585833 0.98 CSF1R (0.51) BRAFCSF1R
SCHEMBL3587792 0.93 CSF1R (0.51) BRAFCSF1R
SCHEMBL3580341 0.93 BRAF (0.46) BRAFCSF1R
SCHEMBL14218733 0.92 CSF1R (0.45) BRAFCSF1R
SCHEMBL3587610 0.91 CSF1R (0.46) BRAFCSF1R
SCHEMBL3588522 0.91 CSF1R (0.46) BRAFCSF1R
SCHEMBL3583692 0.91 BRAF (0.61) BRAF
SCHEMBL3582814 0.90 CSF1R (0.52) BRAFCSF1R
SCHEMBL3589848 0.90 BRAF (0.49) BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008042639-A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS IRM LLC (BM) 2008-04-10 WO disclosed