Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.47 |
| ▸ | LCK | P06239 | 5/20 | 0.47 |
| ▸ | BRAF | P15056 | 11/20 | 0.45 |
| ▸ | RAF1 | P04049 | 6/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3597708 | 0.92 | LCK (0.51) | MAPK14LCKBRAFKDRINSR | |
| SCHEMBL9970885 | 0.88 | BRAF (0.49) | MAPK14LCKBRAFRAF1KDR | |
| SCHEMBL3585282 | 0.85 | BRAF (0.56) | MAPK14LCKBRAFRAF1KDR | |
| SCHEMBL3591864 | 0.84 | LCK (0.56) | MAPK14LCKBRAFRAF1KDR | |
| SCHEMBL3591618 | 0.83 | LCK (0.50) | MAPK14LCKBRAFKDRINSR | |
| SCHEMBL3634395 | 0.83 | LCK (0.61) | MAPK14LCKBRAFRAF1KDR | |
| SCHEMBL3587204 | 0.81 | RAF1 (0.55) | MAPK14BRAFRAF1 | |
| SCHEMBL3591172 | 0.81 | LCK (0.52) | MAPK14LCKBRAFKDRINSR | |
| SCHEMBL13503129 | 0.80 | BRAF (0.47) | MAPK14LCKBRAFRAF1KDR | |
| SCHEMBL3593034 | 0.80 | MAPK14 (0.55) | MAPK14LCKBRAFRAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | disclosed |