Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.72 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.55 |
| ▸ | CDK2 | P24941 | 3/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11931071 | 0.84 | CHEK1 (1.00) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14218609 | 0.83 | CHEK1 (0.74) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931557 | 0.77 | CHEK1 (0.63) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931085 | 0.77 | CHEK1 (0.87) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931084 | 0.76 | CHEK1 (0.84) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14516425 | 0.75 | CHEK1 (0.60) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931233 | 0.74 | CHEK1 (0.80) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931598 | 0.74 | CHEK1 (0.58) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931083 | 0.73 | CHEK1 (1.00) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931075 | 0.73 | CHEK1 (0.79) | CHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008045268-A2 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |