Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 14/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.40 |
| ▸ | SMC2 | O95347 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.36 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.34 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14219735 | 1.00 | MAP2K1 (0.48) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14219846 | 0.92 | MAP2K1 (0.56) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14220180 | 0.91 | MAP2K1 (0.51) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14223197 | 0.89 | MAP2K1 (0.51) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14223056 | 0.89 | MAP2K1 (0.51) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14223200 | 0.88 | MAP2K1 (0.51) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14219681 | 0.87 | MAP2K1 (0.55) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14219650 | 0.87 | MAP2K1 (0.50) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14220127 | 0.87 | MAP2K1 (0.50) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14222510 | 0.82 | MAP2K1 (0.47) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |