Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CHUK | O15111 | 1/20 | 0.30 |
| ▸ | ICOSLG | O75144 | 1/20 | 0.30 |
| ▸ | ICOS | Q9Y6W8 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.30 |
| ▸ | CDK9 | P50750 | 2/20 | 0.30 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1714488 | 0.82 | JAK2 (0.36) | JAK2CHEK1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1714484 | 0.82 | JAK2 (0.36) | JAK2CHEK1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1713526 | 0.81 | JAK2 (0.35) | JAK2CHEK1KLKB1MAP4K1GSK3B | |
| SCHEMBL1713522 | 0.81 | JAK2 (0.35) | JAK2CHEK1KLKB1MAP4K1GSK3B | |
| SCHEMBL1714556 | 0.74 | JAK2 (0.51) | JAK2CHEK1GSK3BALDH1A1HPGD | |
| SCHEMBL1714554 | 0.74 | JAK2 (0.51) | JAK2CHEK1GSK3BALDH1A1HPGD | |
| SCHEMBL1713460 | 0.74 | JAK2 (0.33) | JAK2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1713457 | 0.74 | JAK2 (0.33) | JAK2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1714505 | 0.73 | JAK2 (0.34) | JAK2HPGDGAA | |
| SCHEMBL1714502 | 0.73 | JAK2 (0.34) | JAK2HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008046982-A2 | NEW IMIDAZOLONE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS PROTEIN KINASE INHIBITORS, IN PARTICULAR CDC7 | SANOFI-AVENTIS (FR) | 2008-04-24 | — | — | WO | disclosed |