Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | ACACA | Q13085 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14222614 | 0.92 | EPHX1 (0.40) | GPR119ACACBACACAEPHX1HPGD | |
| SCHEMBL14222041 | 0.88 | EPHX1 (0.43) | EPHX1HPGDRECQLPOLBKDM4E | |
| SCHEMBL14222615 | 0.87 | EPHX1 (0.43) | EPHX1HPGDRECQLPOLBKDM4E | |
| SCHEMBL14222824 | 0.86 | ACACB (0.43) | GPR119ACACBACACAEPHX1HPGD | |
| SCHEMBL14222826 | 0.86 | ACACB (0.41) | GPR119ACACBACACAEPHX1HPGD | |
| SCHEMBL14222822 | 0.86 | EPHX1 (0.42) | EPHX1HPGDRECQLKDM4E | |
| SCHEMBL3495073 | 0.84 | HPGD (0.46) | GPR119EPHX1HPGDRECQLPOLB | |
| SCHEMBL14221912 | 0.80 | ACACB (0.34) | ACACBACACAMEN1KMT2AKDM4E | |
| SCHEMBL3496509 | 0.79 | KMT2A (0.52) | GPR119ACACBACACAEPHX1HPGD | |
| SCHEMBL16992583 | 0.77 | HPGD (0.47) | GPR119EPHX1HPGDRECQLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1911753-A1 | SPIRO-CYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-04-16 | — | — | EP | disclosed |