Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215825 | 0.85 | MAPT (0.57) | GAAMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL213976 | 0.85 | MAPT (0.71) | GAAMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL215229 | 0.83 | MAPT (0.63) | GAAMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL215861 | 0.83 | KMT2A (0.63) | GAAMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL214661 | 0.82 | GAA (0.49) | GAAMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL213701 | 0.82 | MAPT (0.75) | GAAMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL213992 | 0.82 | GAA (0.49) | GAAMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL214708 | 0.82 | GAA (0.49) | GAAMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL2735397 | 0.82 | GAA (0.49) | GAAMAPTALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL215408 | 0.82 | GAA (0.49) | GAAMAPTALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008042282-A2 | IMIDAZOLE-4, 5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | EXELIXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |