Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1816405 | 0.83 | HRH3 (0.53) | HTTFGFR1HRH3 | |
| SCHEMBL24093260 | 0.82 | HTT (0.47) | HTTFGFR1LMNATSHRNPSR1 | |
| Hydrochloric Acid SCHEMBL1816217 | 0.82 | HRH3 (0.52) | HTTFGFR1HRH3 | |
| SCHEMBL1814415 | 0.82 | HRH3 (0.52) | HTTFGFR1HRH3 | |
| SCHEMBL4942172 | 0.81 | MKNK1 (0.50) | HTTFGFR1ALDH1A1 | |
| SCHEMBL24093258 | 0.81 | HTT (0.45) | HTTFGFR1HRH3ALDH1A1 | |
| SCHEMBL19567982 | 0.81 | HTT (0.45) | HTTFGFR1HRH3 | |
| SCHEMBL31005276 | 0.80 | HTT (0.66) | HTTFGFR1HRH3 | |
| SCHEMBL26020064 | 0.80 | HTT (0.44) | HTTFGFR1LMNATSHRNPSR1 | |
| SCHEMBL3419279 | 0.79 | HTT (0.88) | HTTFGFR1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008045371-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-04-17 | — | — | WO | disclosed |