Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.49 |
| ▸ | BCR | P11274 | 3/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.46 |
| ▸ | AIMP2 | Q13155 | 2/20 | 0.46 |
| ▸ | ABL2 | P42684 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 4/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224133 | 0.94 | ABL1 (0.50) | ABL1BCREPHX2AIMP2ABL2 | |
| SCHEMBL14224075 | 0.93 | AIMP2 (0.48) | ABL1BCRAIMP2EGFRSYK | |
| SCHEMBL14195979 | 0.92 | MTOR (0.54) | ABL1BCREPHX2AIMP2ABL2 | |
| SCHEMBL14224454 | 0.92 | AIMP2 (0.47) | ABL1BCREPHX2AIMP2EGFR | |
| SCHEMBL14224359 | 0.91 | AIMP2 (0.48) | ABL1BCRAIMP2EGFRSYK | |
| SCHEMBL14224455 | 0.91 | SYK (0.47) | ABL1BCREPHX2AIMP2EGFR | |
| SCHEMBL14224140 | 0.91 | AIMP2 (0.50) | ABL1BCRAIMP2EGFRSYK | |
| SCHEMBL14196020 | 0.90 | ABL1 (0.59) | ABL1BCREPHX2AIMP2ABL2 | |
| SCHEMBL14224273 | 0.90 | AIMP2 (0.45) | ABL1BCRAIMP2EGFRSYK | |
| SCHEMBL14224357 | 0.88 | AIMP2 (0.48) | ABL1BCRAIMP2EGFRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |