Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AIMP2 | Q13155 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | BCR | P11274 | 2/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 5/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224359 | 0.94 | AIMP2 (0.48) | AIMP2EGFRSRCABL1BCR | |
| SCHEMBL14224358 | 0.93 | AIMP2 (0.49) | AIMP2EGFRSRCABL1BCR | |
| SCHEMBL14224093 | 0.93 | SYK (0.49) | AIMP2EGFRSRCABL1BCR | |
| SCHEMBL14196029 | 0.92 | AIMP2 (0.49) | AIMP2EGFRSRCABL1BCR | |
| SCHEMBL14224274 | 0.92 | AIMP2 (0.51) | AIMP2EGFRSRCABL1BCR | |
| SCHEMBL14195967 | 0.92 | AIMP2 (0.51) | AIMP2EGFRSRCABL1BCR | |
| SCHEMBL14196022 | 0.92 | AIMP2 (0.51) | AIMP2EGFRSRCABL1BCR | |
| SCHEMBL14224356 | 0.92 | AIMP2 (0.48) | AIMP2EGFRSRCABL1BCR | |
| SCHEMBL14195960 | 0.92 | ABL1 (0.53) | AIMP2EGFRSRCABL1BCR | |
| SCHEMBL14224272 | 0.91 | AIMP2 (0.45) | AIMP2EGFRSRCABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |