Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 4/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224085 | 0.93 | ABL1 (0.42) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL14195972 | 0.92 | GSK3B (0.45) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL14195959 | 0.92 | ABL1 (0.49) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL14224453 | 0.92 | SYK (0.41) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL14195987 | 0.88 | GSK3B (0.42) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL14196023 | 0.87 | AIMP2 (0.45) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL14224451 | 0.85 | AIMP2 (0.47) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL14196029 | 0.85 | AIMP2 (0.49) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL14196038 | 0.84 | SYK (0.50) | ABL1EGFRBCRSRCPRKCA | |
| SCHEMBL13924562 | 0.81 | SYK (0.56) | ABL1EGFRBCRSRCPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |