Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 3/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224074 | 0.93 | AIMP2 (0.44) | SYKAIMP2ABL1BCREGFR | |
| SCHEMBL14224272 | 0.93 | AIMP2 (0.45) | SYKAIMP2ABL1BCREGFR | |
| SCHEMBL14196023 | 0.92 | AIMP2 (0.45) | SYKAIMP2ABL1BCREGFR | |
| SCHEMBL14224093 | 0.92 | SYK (0.49) | SYKAIMP2ABL1BCREGFR | |
| SCHEMBL14195968 | 0.91 | AIMP2 (0.46) | SYKAIMP2ABL1BCREGFR | |
| SCHEMBL14224091 | 0.91 | SYK (0.49) | SYKAIMP2ABL1BCREGFR | |
| SCHEMBL14196027 | 0.90 | AIMP2 (0.46) | SYKAIMP2ABL1BCREGFR | |
| SCHEMBL14195958 | 0.89 | ABL1 (0.51) | SYKAIMP2ABL1BCREGFR | |
| SCHEMBL14195989 | 0.86 | AIMP2 (0.45) | SYKAIMP2ABL1BCREGFR | |
| SCHEMBL14224355 | 0.86 | SYK (0.55) | SYKABL1BCREGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |