Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.55 |
| ▸ | CDK2 | P24941 | 15/20 | 0.55 |
| ▸ | SGK1 | O00141 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1600691 | 0.91 | AKT1 (0.65) | AKT1CDK2 | |
| SCHEMBL1600696 | 0.91 | AKT1 (0.65) | AKT1CDK2 | |
| SCHEMBL1600693 | 0.91 | AKT1 (0.65) | AKT1CDK2 | |
| SCHEMBL1600776 | 0.90 | AKT1 (0.67) | AKT1CDK2SGK1 | |
| SCHEMBL1600774 | 0.90 | AKT1 (0.67) | AKT1CDK2SGK1 | |
| SCHEMBL1600778 | 0.90 | AKT1 (0.67) | AKT1CDK2SGK1 | |
| SCHEMBL1600922 | 0.81 | AKT1 (0.68) | AKT1CDK2 | |
| SCHEMBL1600919 | 0.81 | AKT1 (0.68) | AKT1CDK2 | |
| SCHEMBL1600926 | 0.81 | AKT1 (0.68) | AKT1CDK2 | |
| SCHEMBL1600709 | 0.74 | AKT1 (0.60) | AKT1CDK2SGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354944-B2 | Thiadiazole compounds and methods of use | AMGEN INC. (US) | 2008-04-08 | — | — | US | disclosed |