Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14197617 | 1.00 | MAPT (0.38) | MAPTSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL23180607 | 0.74 | HPGD (0.41) | MAPTSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL10412422 | 0.72 | HDAC1 (0.47) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL9331716 | 0.72 | HDAC1 (0.47) | MAPTSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL6139665 | 0.70 | MAPT (0.39) | MAPTSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL5225981 | 0.70 | BACE1 (0.39) | MAPTSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL6139668 | 0.70 | MAPT (0.39) | MAPTSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL5229133 | 0.70 | MAPT (0.39) | MAPTSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL5229354 | 0.70 | BACE1 (0.39) | MAPTSMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL6139928 | 0.70 | BACE1 (0.39) | MAPTSMN1; SMN2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354946-B2 | prominent growth inhibitory activity against tumor cells; cyclin dependent kinase inhibitors; colon cancer; N'-(3-t-butylisoindolino[3,2-b]oxazolidin-4-on-8-yl)-N-(4-(N-benzylpyrrolidin-3-yl)pyridin-2-yl)urea | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-04-08 | — | — | US | disclosed |