Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | POLQ | O75417 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.32 |
| ▸ | LIPE | Q05469 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 2/20 | 0.31 |
| ▸ | PDE6D | O43924 | 1/20 | 0.31 |
| ▸ | PDE6A | P16499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1422607 | 1.00 | GPBAR1 (0.34) | GPBAR1POLQHCRTR1HCRTR2SCN9A | |
| SCHEMBL1422029 | 0.83 | POLQ (0.35) | POLQHCRTR1HCRTR2LTC4SLIPE | |
| SCHEMBL1422024 | 0.83 | POLQ (0.35) | POLQHCRTR1HCRTR2LTC4SLIPE | |
| SCHEMBL1422500 | 0.82 | KDM4E (0.37) | GPBAR1POLQHCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL1422501 | 0.82 | KDM4E (0.37) | GPBAR1POLQHCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL264286 | 0.81 | MEN1 (0.39) | GPBAR1POLQHCRTR1HCRTR2SCN9A | |
| SCHEMBL264284 | 0.81 | MEN1 (0.39) | GPBAR1POLQHCRTR1HCRTR2SCN9A | |
| SCHEMBL264285 | 0.81 | MEN1 (0.39) | GPBAR1POLQHCRTR1HCRTR2SCN9A | |
| SCHEMBL1421840 | 0.79 | HCRTR1 (0.34) | POLQHCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL1421842 | 0.79 | HCRTR1 (0.34) | POLQHCRTR1HCRTR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297102-A1 | HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2011-03-23 | — | — | EP | claimed |