SCHEMBL1422702 — predicted protein targets

Predicted protein targets (top 16)

	gene	UniProt	supporting neighbours	confidence
▸	BTK	Q06187	11/20	0.35

▸	FGR	P09769	1/20	0.35

▸	SRC	P12931	1/20	0.35

▸	TEC	P42680	1/20	0.35

▸	BMX	P51813	1/20	0.35

▸	CDK6	Q00534	2/20	0.35

▸	CCND1	P24385	1/20	0.35

▸	HTR1F	P30939	5/20	0.33

▸	CDK4	P11802	1/20	0.31

▸	HTR1A	P08908	4/20	0.31

▸	HTR1D	P28221	3/20	0.31

▸	HTR1B	P28222	3/20	0.31

▸	HTR2A	P28223	1/20	0.30

▸	HTR2C	P28335	1/20	0.30

▸	HTR1E	P28566	1/20	0.30

▸	HTR4	Q13639	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1422549	0.91	BTK (0.43)	BTKFGRSRCTECBMX
SCHEMBL1422358	0.90	BTK (0.40)	BTKFGRSRCTECBMX
SCHEMBL1422824	0.90	BTK (0.42)	BTKFGRSRCTECBMX
SCHEMBL1422703	0.85	CDK6 (0.40)	BTKFGRTECBMXCDK6
SCHEMBL1422626	0.84	BTK (0.37)	BTKFGRSRCTECBMX
SCHEMBL1422505	0.78	CDK4 (0.38)	BTKFGRTECBMXCDK6
SCHEMBL1423152	0.78	CDK6 (0.41)	BTKFGRTECBMXCDK6
SCHEMBL1422829	0.78	CCND1 (0.40)	BTKFGRSRCTECBMX
SCHEMBL1422360	0.78	BTK (0.39)	BTKFGRTECBMXCDK6
SCHEMBL1422539	0.77	BTK (0.39)	BTKFGRSRCTECBMX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2297105-A1	SUBSTITUTED AMIDES, METHOD OF MAKING, AND USE AS BTK INHIBITORS	CGI Pharmaceuticals, Inc. (US)	2011-03-23	—	—	EP	disclosed