Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14228569 | 0.99 | HRH3 (0.38) | HRH3KCNH2ADRA2AADRA2BHTR4 | |
| SCHEMBL9922927 | 0.95 | HRH3 (0.36) | HRH3KCNH2ADRA2AADRA2BHTR4 | |
| SCHEMBL9922709 | 0.93 | P2RY12 (0.37) | HRH3KCNH2ADRA2AADRA2BHTR4 | |
| SCHEMBL9922918 | 0.92 | P2RY12 (0.37) | HRH3KCNH2ADRA2AADRA2BHTR4 | |
| SCHEMBL9922925 | 0.89 | P2RY12 (0.39) | HRH3KCNH2ADRA2AADRA2BHTR4 | |
| SCHEMBL12161248 | 0.88 | P2RY12 (0.39) | HRH3KCNH2ADRA2AADRA2BHTR4 | |
| SCHEMBL12177251 | 0.87 | HRH3 (0.38) | HRH3KCNH2 | |
| SCHEMBL9922917 | 0.86 | KMT2A (0.46) | — | |
| SCHEMBL12177212 | 0.86 | P2RY12 (0.34) | — | |
| SCHEMBL14113594 | 0.85 | HRH3 (0.42) | HRH3KCNH2ADRA2AADRA2BHTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358257-B2 | sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives; effective for prevention and treatment of cardiovascular diseases, antithrombotic agents | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-04-15 | — | — | US | disclosed |