Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CD4 | P01730 | 3/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1422860 | 0.99 | HRH3 (0.53) | HRH3ALDH1A1TSHRRECQLPOLB | |
| SCHEMBL2907958 | 0.92 | HRH3 (0.55) | HRH3ALDH1A1TSHRRECQLPOLB | |
| SCHEMBL2907126 | 0.91 | HRH3 (0.53) | HRH3ALDH1A1TSHRRECQLPOLB | |
| SCHEMBL1422794 | 0.90 | HRH3 (0.67) | HRH3ESR2KCNH2 | |
| SCHEMBL1423049 | 0.90 | HRH3 (0.52) | HRH3ALDH1A1TSHRRECQLL3MBTL1 | |
| SCHEMBL1422936 | 0.89 | HRH3 (0.66) | HRH3ALDH1A1ESR1ESR2KDM4E | |
| SCHEMBL1422845 | 0.89 | HRH3 (0.53) | HRH3ALDH1A1TSHRL3MBTL1KDM4E | |
| SCHEMBL1423087 | 0.88 | HRH3 (0.49) | HRH3ALDH1A1TSHRRECQLPOLB | |
| SCHEMBL1423482 | 0.87 | HRH3 (0.47) | HRH3ALDH1A1TSHRRECQLPOLB | |
| SCHEMBL1422943 | 0.86 | HRH3 (0.64) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102214-B1 | 4, 5, 6, 7-TETRAHYDRO-THIENO [3, 2-C] PYRIDINE DERIVATIVES AS H3 MODULATORS | HOFFMANN LA ROCHE (CH) | 2011-03-23 | — | — | EP | claimed |
| US-7557101-B2 | 4,5,6,7-tetrahydro-thieno[3,2-c] pyridine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-07-07 | — | — | US | claimed |
| US-20080146558-A1 | 4,5,6,7-Tetrahydro-Thieno [3,2-C] Pyridine Derivatives | HOFFMANN-LA ROCHE, INC. | 2008-06-19 | — | — | US | claimed |
| EP-2102214-B1 | 4, 5, 6, 7-TETRAHYDRO-THIENO [3, 2-C] PYRIDINE DERIVATIVES AS H3 MODULATORS | HOFFMANN LA ROCHE (CH) | 2011-03-23 | — | — | EP | disclosed |
| US-7557101-B2 | 4,5,6,7-tetrahydro-thieno[3,2-c] pyridine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-07-07 | — | — | US | disclosed |
| US-20080146558-A1 | 4,5,6,7-Tetrahydro-Thieno [3,2-C] Pyridine Derivatives | HOFFMANN-LA ROCHE, INC. | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146558-A1 | 4,5,6,7-Tetrahydro-Thieno [3,2-C] Pyridine Derivatives | HRH4, HRH3, HRH2 | HRH3 2/4885ALDH1A1 362/4885TSHR 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.