Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.77 |
| ▸ | CCNA2 | P20248 | 16/20 | 0.77 |
| ▸ | CDK2 | P24941 | 16/20 | 0.77 |
| ▸ | CCNA1 | P78396 | 16/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11930896 | 0.87 | CHEK1 (0.73) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11930771 | 0.85 | CHEK1 (1.00) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11937079 | 0.83 | CHEK1 (1.00) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11930950 | 0.83 | CHEK1 (0.74) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931270 | 0.83 | CHEK1 (1.00) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14232402 | 0.83 | CHEK1 (0.71) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11930892 | 0.82 | CHEK1 (0.69) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL12473548 | 0.82 | CHEK1 (0.69) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11930943 | 0.82 | CHEK1 (0.69) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11930931 | 0.82 | CHEK1 (0.75) | CHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008045267-A2 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-04-17 | — | — | WO | disclosed |