Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 20/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 13/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | HCK | P08631 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.56 |
| ▸ | SIK1 | P57059 | 1/20 | 0.56 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.56 |
| ▸ | WNK3 | Q9BYP7 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237142 | 0.97 | AURKA (0.56) | AURKAAURKBMAPK13CHEK2NTRK1 | |
| SCHEMBL6521497 | 0.89 | AURKA (0.61) | AURKAAURKBMAPK13CHEK2NTRK1 | |
| SCHEMBL14237170 | 0.87 | AURKA (0.65) | AURKAAURKBMAPK13CHEK2NTRK1 | |
| SCHEMBL14237265 | 0.86 | AURKA (0.64) | AURKAAURKBMAPK13CHEK2NTRK1 | |
| SCHEMBL3454765 | 0.86 | AURKA (0.61) | AURKAAURKBMAPK13CHEK2NTRK1 | |
| SCHEMBL14237210 | 0.86 | AURKA (0.61) | AURKAAURKBMAPK13CHEK2NTRK1 | |
| SCHEMBL3454463 | 0.83 | AURKA (0.64) | AURKAAURKBMAPK13CHEK2NTRK1 | |
| SCHEMBL14237291 | 0.83 | AURKA (0.61) | AURKAAURKBMAPK13CHEK2NTRK1 | |
| SCHEMBL14237184 | 0.82 | AURKA (0.74) | AURKAAURKBMAPK13CHEK2NTRK1 | |
| SCHEMBL3455059 | 0.81 | AURKA (0.67) | AURKAAURKBMAPK13CHEK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254889-B1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2012-12-19 | — | — | EP | claimed |