Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.50 |
| ▸ | ATR | Q13535 | 5/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3460680 | 0.91 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CGPIK3CBEGFR | |
| SCHEMBL3459614 | 0.90 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3460635 | 0.89 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3460417 | 0.88 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3461419 | 0.88 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3461559 | 0.87 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3462401 | 0.86 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3461401 | 0.86 | PIK3CD (0.62) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3461290 | 0.86 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3462532 | 0.86 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CGPIK3CBATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | claimed |
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | disclosed |