Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 12/20 | 0.61 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237342 | 0.89 | SCN10A (0.69) | SCN10ASCN9ASCN2ASCN3ASCN1A | |
| SCHEMBL263791 | 0.87 | SCN10A (0.60) | SCN10ASCN9ASCN2ASCN3ASCN1A | |
| SCHEMBL2414024 | 0.86 | SCN10A (0.55) | SCN10ANPC1RAB9ANPSR1GMNN | |
| SCHEMBL14237554 | 0.81 | SCN10A (0.80) | SCN10ASCN9ASCN2ASCN3ASCN1A | |
| SCHEMBL14237414 | 0.80 | SCN10A (0.62) | SCN10ASCN9ASCN2ASCN3ASCN1A | |
| SCHEMBL264142 | 0.80 | SCN10A (0.61) | SCN10ASCN9ASCN2ASCN3ASCN1A | |
| SCHEMBL14237600 | 0.80 | SCN10A (0.64) | SCN10ASCN9ASCN2ASCN3ASCN1A | |
| SCHEMBL12155422 | 0.80 | SCN10A (0.67) | SCN10ASCN9ASCN2ASCN3ASCN1A | |
| SCHEMBL12241082 | 0.79 | SCN10A (0.64) | SCN10ASCN9ASCN2ASCN3ASCN1A | |
| SCHEMBL14237501 | 0.78 | SCN10A (0.62) | SCN10ASCN9ASCN2ASCN3ASCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183241-B1 | 2-PYRIDINE CARBOXAMIDE DERIVATIVES AS SODIUM CHANNEL MODULATORS | PFIZER LTD (GB) | 2012-12-19 | — | — | EP | disclosed |