Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.55 |
| ▸ | ATR | Q13535 | 12/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | LDHB | P07195 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3834464 | 1.00 | USP30 (0.55) | USP30ATRADORA3ADORA2AADORA2B | |
| SCHEMBL3461713 | 0.90 | ATR (0.59) | ATRLDHALDHB | |
| SCHEMBL3461171 | 0.90 | ATR (0.59) | ATRLDHALDHB | |
| SCHEMBL3462558 | 0.88 | ATR (0.58) | ATRLDHALDHB | |
| SCHEMBL3459637 | 0.88 | ATR (0.58) | ATRLDHALDHB | |
| SCHEMBL3462372 | 0.88 | ATR (0.59) | USP30ATR | |
| SCHEMBL3460566 | 0.86 | USP30 (0.59) | USP30ATR | |
| SCHEMBL3459975 | 0.86 | USP30 (0.55) | USP30ATR | |
| SCHEMBL3462051 | 0.84 | ATR (0.53) | USP30ATR | |
| SCHEMBL3461200 | 0.83 | ATR (0.54) | USP30ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | claimed |